Publications

Micro- And Nanomaterials Based Detection Systems Applied in Lab-On-A-Chip Technology

Mariana Medina-Sánchez, Arben Merkoçi. Handbook of Green Analytical Chemistry (eds M. de la Guardia and S. Garrigues), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119940722.ch18
This chapter contains sections titled: Micro- and nanotechnology in Green Analytical Chemistry Nanomaterials-based (bio)sensors Lab-on-a-chip (LOC) technology LOC applications Conclusions and future perspectives References   [Link to the article] [Ask for pdf]

Nanochannels Preparation and Application in Biosensing

Alfredo de la Escosura-Muñiz, Arben Merkoçi. ACS Nano, 2012, 6, 7556–7583
Selective transport in nanochannels (protein-based ion channels) is already used in living systems for electrical signaling in nerves and muscles and this natural behavior is being approached for the application of biomimetic nanochannels in biosensors. Based on this principle single nanochannels and nanochannels arrays seem to bring...

Carbon nanotubes and graphene in analytical sciences

Briza Pérez-López, Arben Merkoçi. Microchimica Acta, 2012, 179, 1-16
Nanosized carbon materials are offering great opportunities in various areas of nanotechnology. Carbon nanotubes and graphene, due to their unique mechanical, electronic, chemical, optical and electrochemical properties, represent the most interesting building blocks in various applications where analytical chemistry is of special importance....

Simple Monitoring of Cancer Cells Using Nanoparticles

Marisa Maltez-da Costa, Alfredo de la Escosura-Muñiz, Carme Nogués, Lleonard Barrios, Elena Ibáñez, Arben Merkoçi. Nanoletters, 2012, 12, 4164−4171
Here we present a new strategy for a simple and fast detection of cancer circulating cells (CTCs) using nanoparticles. The human colon adenocarcinoma cell line (Caco2) was chosen as a model CTC. Similarly to other adenocarcinomas, colon adenocarcinoma cells have a strong expression of EpCAM, and for this reason this glycoprotein...

Signal enhancement in antibody microarrays using quantum dots nanocrystals: Application to potential Alzheimer’s disease biomarker screening

Eden Morales-Narváez, Helena Montón, Anna Fomicheva, Arben Merkoçi. Anal. Chem., 2012, 84 (15), pp 6821–6827
The performance of cadmium-selenide/zinc-sulfide (CdSe@ZnS) quantum dots (QDs) and the fluorescent dye Alexa 647 as reporter in an assay designed to detect apolipoprotein E (ApoE) has been compared. The assay is a sandwich immunocomplex microarray that functions via excitation by visible light. ApoE was chosen for its potential...

Controlled formation of nanostructurated CaCO3-PEI microparticles with high biofunctionalizing capacity

Adaris López-Marzo, Josefina Pons, Arben Merkoçi. Journal of Materials Chemistry, 2012, 22, 15326–15335
Nanostructured vaterite microparticles formation with high biofunctionalizing capacity for biosensing platforms using a water/organic solvent mixture with poly(ethyleneimine) (PEI) under sonication mixing conditions has been studied. A novel and effective polymorph  discrimination is found with this system. Pure rhombohedra calcite...

Graphene Oxide as an Optical Biosensing Platform

Eden Morales-Narváez, Arben Merkoçi. Advanced Materials, 2012, 24, 3298–3308
Since graphene exhibits innovative mechanical, electrical, thermal, and  optical properties, this 2D material is increasingly attracting attention and is under active research. Among the various graphene forms with lattice-like nanostructure, graphene oxide (GO) displays advantageous characteristics as a biosensing platform due...

On-chip electrochemical detection of CdS quantum dots using normal and multiple recycling flow through modes

Mariana Medina-Sánchez, Sandrine Miserere, Sergio Marín, Gemma Aragay, Arben Merkoçi. Lab Chip, 2012, 12, 2000–2005
A flexible hybrid polydimethylsiloxane (PDMS)–polycarbonate (PC) microfluidic chip with integrated screen printed electrodes (SPE) was fabricated and applied for electrochemical quantum dots (QDs) detection. The developed device combines the advantages of flexible microfluidic chips, such as their low cost, the possibility to...

Nanomaterials application in electrochemical detection of heavy metals

Gemma Aragay, Arben Merkoçi. Electrochimica Acta, 2012, 84, 49–61
Recent trends in the application of nanomaterials for electrochemical detection of heavy metals are shown. Various nanomaterials such as nanoparticles, nanowires, nanotubes, nanochannels, graphene, etc. have been explored either as modifiers of electrodes or as new electrode materials with interest to be applied in electrochemical...

Superhydrophobic Alkanethiol-Coated Microsubmarines for Effective Removal of Oil

Maria Guix, Jahir Orozco, Miguel García, Wei Gao, Sirilak Sattayasamitsathit, Arben Merkoçi, Alberto Escarpa, Joseph Wang. ACS Nano, 2012, 6, 4445-4451
We demonstrate the use of artificial nanomachines for effective interaction, capture, transport, and removal of oil droplets. The simple nanomachine-enabled oil collection method is based on modifying microtube engines with a superhydrophobic layer able to adsorb oil by means of its strong adhesion to a long chain of self-assembled...