Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassay

Claudio Parolo, Mariana Medina-Sánchez, Alfredo de la Escosura-Muñiz, Arben Merkoçi. Lab Chip, 2013,13, 386-390

Lateral flow immunoassay (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity avoids their extensive use. We report a strategy that yields up to an 8-fold improvement in a gold nanoparticles-based LFIA, changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in concordance with the experimental results.

[Link to the article]

[Ask for pdf]