Graphene Oxide-Poly(dimethylsiloxane)-Based Lab-on-a-Chip Platform for Heavy-Metals Preconcentration and Electrochemical Detection

Andrzej Chalupniak, Arben Merkoçi. ACS Applied Materials & Interfaces
Herein, we present the application of a novel graphene oxide-poly(dimethylsiloxane) (GO-PDMS) composite in reversible adsorption/desorption, including detection of heavy metals. GO-PDMS was fabricated by simple blending of GO with silicon monomer in the presence of tetrahydrofuran, followed by polymerization initiated upon the addition...

In situ monitoring of PTHLH secretion in neuroblastoma cells cultured onto nanoporous membranes

Alfredo de la Escosura-Muñiz, Marisol Espinoza-Casteñeda, Alejandro Chamorro-Garcia, Carlos J. Rodríguez-Hernández, Carmen de Torres, Arben Merkoçi. Biosensors & Bioelectronics
In this work, we propose for the first time the use of anodic aluminum oxide (AAO) nanoporous membranes for in situ monitoring of parathyroid hormone-like hormone (PTHLH) secretion in cultured human cells. The biosensing system is based on the nanochannels blockage upon immunocomplex formation, which is electrically monitored through...

Architecting Graphene Oxide Rolled-Up Micromotors: A Simple Paper-Based Manufacturing Technology

Luis Baptista Pires, Jahir Orozco, Pablo Guardia, Arben Merkoçi. Small, Available online 24 November 2017, doi: 10.1002/smll.201702746
A graphene oxide rolled-up tube production process is reported using wax-printed membranes for the fabrication of on-demand engineered micromotors at different levels of oxidation, thickness, and lateral dimensions. The resultant graphene oxide rolled-up tubes can show magnetic and catalytic movement within the addition of magnetic...

Nanomaterials connected to antibodies and molecularly imprinted polymers as bio/receptors for bio/sensor applications

Alejandro Zamora, Eden Morales-Narváez, Carmen C. Mayorga-Martínez, Arben Merkoçi. Applied Materials Today, Available online December 2017, doi: 10.1016/j.apmt.2017.09.006
Nowadays, nanomaterials are considered a pivotal tool for different fields such as textiles, energy, environment, electronics, photonics, food, agriculture, biomedicine and health care. This is due to their advantageous properties coming from their high surface area, among other physicochemical properties, compared to their respective...

Photoluminescent lateral flow based on non-radiative energy transfer for protein detection in human serum

Alejandro Zamora, Eden Morales-Narváez, Arben Merkoçi. Biosensors and Bioelectronics, Available online 15 February 2018, doi: 10.1016/j.bios.2017.09.013
A new paper-based lateral flow immunoassay configuration was engineered and investigated. The assay is intended for the detection of a model protein in human serum, that is, human immunoglobulin G, with the aim to demonstrate a virtually universal protein detection platform. Once the sample is added in the strip, the analyte is selectively...

Nanocellulose in Sensing and Biosiensing

Hamed Golmohammadi, Eden Morales-Narváez, Tina Naghdi, Arben Merkoçi. Chemistry of Materials, Available online 9 June 2017, doi: 10.1021/acs.chemmater.7b01170
Because of its multifunctional character, nanocellulose (NC) is one of the most interesting nature-based nanomaterials and is attracting attention in a myriad of fields such as biomaterials, engineering, biomedicine, opto/electronic devices, nanocomposites, textiles, cosmetics and food products. Moreover, NC offers a plethora of...

Bioluminescent nanopaper for rapid screening of toxic substances

Jie Liu, Eden Morales-Narváez, Jahir Orozco, Teresa Vincent, Guohua Zhong, Arben Merkoçi. NanoResearch, Available online 2 August 2017, doi: 10.1007/s12274-017-1610-7
Environmental pollution is threatening human health and ecosystems as a result of modern agricultural techniques and industrial progress. A simple nanopaper-based platform coupled with luminescent bacteria Aliivibrio fischeri (A. fischeri) as a bio-indicator is presented here, for rapid and sensitive evaluation of contaminant toxicity....

Production of biofunctionalized MoS2 flakes with rationally modified lysozyme: a biocompatible 2D hybrid material

Marialuisa Siepi, Eden Morales-Narváez, Neus Domingo, Daria Maria Monti, Eugenio Notomista, Arben Merkoçi. 2D Materials, Available Online 2 July 2017, doi: 10.1088/2053-1583/aa7966
Bioapplications of 2D materials embrace demanding features in terms of environmental impact, toxicity and biocompatibility. Here we report on the use of a rationally modified lysozyme to assist the exfoliation of MoS2 bulk crystals suspended in water through ultrasonic exfoliation. The design of the proposed lysozyme derivative...

Graphene-encapsulated materials: Synthesis, applications and trends

Eden Morales-Narváez, Livia Florio, Sergio Antonio Spinola, Arben Merkoçi. Progress in Materials Science, Available online May 2017, 10.1016/j.pmatsci.2017.01.001
Graphene-based materials (GBM) are an exceptional type of materials that offer unprecedented application capabilities to the scientific and technologic community. The encapsulation of different materials such as drugs, nanoparticles, polymers, oxides and cells by GBM is leading to outstanding hybrid materials with unprecedented behaviours...

Straightforward Immunosensing Platform Based on Graphene Oxide-Decorated Nanopaper: A Highly Sensitive and Fast Biosensing Approach

Nopchulee Cheeveewattanagul, Eden Morales-Narváez, Abel-Rahin H. A. Hassan, José Francisco Bergua, Arben Merkoçi. Advanced Functional Materials, Available online 11 August 2017, doi: 10.1002/adfm.201702741
Immunoassays are nowadays a crucial tool for diagnostics and drug development. However, they often involve time-consuming procedures and need at least two antibodies in charge of the capture and detection processes, respectively. This study reports a nanocomposite based on graphene oxide-coated nanopaper (GONAP) facilitating an advantageous...