Rapid on-chip apoptosis assay on human carcinoma cells based on annexin-V / quantum dot probes

Helena Montón, Mariana Medina-Sánchez, Joan Antoni Soler, Andrzej Chałupniak, Carme Nogués, Arben Merkoçi. Biosensors and Bioelectronics, Available online 18 March 2017, http://dx.doi.org/10.1016/j.bios.2017.03.034
Despite all the efforts made over years to study the cancer expression and the metastasis event, there is not a clear understanding of its origins and effective treatment. Therefore, more specialized and rapid techniques are required for studying cell behaviour under different drug-based treatments. Here we present a quantum dot...

Toward integrated detection and graphene-based removal of contaminants in a lab-on-a-chip platform

Andrzej Chałupniak, Arben Merkoçi. Nano Research (2017), doi:10.1007/s12274-016-1420-3
A novel, miniaturized microfluidic platform was developed for the simultaneous detection and removal of polybrominated diphenyl ethers (PBDEs). The platform consists of a polydimethylsiloxane (PDMS) microfluidic chip for an immunoreaction step, a PDMS chip with an integrated screen-printed electrode (SPCE) for detection, and a PDMS-reduced...

Graphene-Based Biosensors: Going Simple

Eden Morales-Narváez, Luis Baptista-Pires, Alejandro Zamora-Gálvez, and Arben Merkoçi.
The main properties of graphene derivatives facilitating optical and electrical biosensing platforms are discussed, along with how the integration of graphene derivatives, plastic, and paper can lead to innovative devices in order to simplify biosensing technology and manufacture easy-to-use, yet powerful electrical or optical biosensors....

Mobile phone–based biosensing: an emerging “diagnostic and communication” technology

Daniel Quesada-González, Arben Merkoçi.
In this review we discuss recent developments on the use of mobile phones and similar devices for biosensing applications in which diagnostics and communications are coupled. Owing to the capabilities of mobile phones (their cameras, connectivity, portability, etc.) and to advances in biosensing, the coupling of these two technologies...

Paper-based sensors and assays: a success of the engineering design and the convergence of knowledge areas

Adaris M. López-Marzo and Arben Merkoçi.
This review shows the recent advances and state of the art in paper-based analytical devices (PADs) through the analysis of their integration with microfluidics and LOC micro- and nanotechnologies, electrochemical/optical detection and electronic devices as the convergence of various knowledge areas. The important role of the paper...

Nanomaterials-based enzyme electrochemical biosensors operating through inhibition for biosensing applications

Sevinc Kurbanoglu, Sibel A. Ozkan, Arben Merkoçi..
In recent years great progress has been made in applying nanomaterials to design novel biosensors. Use of nanomaterials offers to biosensing platforms exceptional optical, electronic and magnetic properties. Nanomaterials can increase the surface of the transducing area of the sensors that in turn bring an increase in catalytic behaviors....

Biosensors for plant pathogen detection

Mohga Khater, Alfredo de la Escosura-Muñiz, Arben Merkoçi..
Infectious plant diseases are caused by pathogenic microorganisms such as fungi, bacteria, viruses, viroids, phytoplasma and nematodes. Worldwide, plant pathogen infections are among main factors limiting crop productivity and increasing economic losses. Plant pathogen detection is important as first step to manage a plant disease...

High-performance sensor based on copper oxide nanoparticles for dual detection of phenolic compounds and a pesticide

F. Pino, C.C. Mayorga-Martinez, A. Merkoçi. Electrochemistry Communications, Volume 71, October 2016, Pages 33–37
The development of nanomaterials for use as bio-recognition elements is important in the evolution of biosensing systems. In the present article we present a sensing system based on copper oxide nanoparticles (CuO NPs) for the detection of phenolic compounds and pesticides. This sensor takes advantage of the interactions of CuO NPs...

Electrochemically reduced graphene and iridium oxide nanoparticles for inhibition-based angiotensin-converting enzyme inhibitor detection

Sevinc Kurbanoglu, Lourdes Rivas, Sibel A. Ozkan, Arben Merkoçi. Biosensors and Bioelectronics, Available online 30 July 2016 In Press
In this work, a novel biosensor based on electrochemically reduced graphene oxide and iridium oxide nanoparticles for the detection of angiotensin-converting enzyme inhibitor drug, captopril, is presented. For the preparation of the biosensor, tyrosinase is immobilized onto screen printed electrode by using 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide...

Graphene-based hybrid for enantioselective sensing applications

Erhan Zor, Eden Morales-Narváez, Sabri Alpaydin, Haluk Bingol, Mustafa Ersoz, Arben Merkoçi. Biosensors and Bioelectronics, Volume 87, 15 January 2017, Pages 410–416
Chirality is a major field of research of chemical biology and is essential in pharmacology. Accordingly, approaches for distinguishing between different chiral forms of a compound are of great interest. We report on an efficient and generic enantioselective sensor that is achieved by coupling reduced graphene oxide with γ-cyclodextrin...