Straightforward Immunosensing Platform Based on Graphene Oxide-Decorated Nanopaper: A Highly Sensitive and Fast Biosensing Approach

Abdel-Rahim H. A. Hassan, Arben Merkoçi, Eden Morales-Narváez, José Francisco Bergua, Nopchulee Cheeveewattanagul Advanced Functional Materials, Available online 11 August 2017, doi: 10.1002/adfm.201702741
Immunoassays are nowadays a crucial tool for diagnostics and drug development. However, they often involve time-consuming procedures and need at least two antibodies in charge of the capture and detection processes, respectively. This study reports a nanocomposite based on graphene oxide-coated nanopaper (GONAP) facilitating an advantageous...

Paper strip-embedded graphene quantum dots: a screening device with a smartphone readout

Jahir Orozco, Ruslan Álvarez Diduk Scientific Reports, Available online 20 April 2017, doi: 10.1038/s41598-017-01134-3
Simple, inexpensive and rapid sensing systems are very demanded for a myriad of uses. Intrinsic properties of emerging paper-based analytical devices have demonstrated considerable potential to fulfill such demand. This work reports an easy-to-use, low cost, and disposable paper-based sensing device for rapid chemical screening with...

Magnetic nanoparticle-molecular imprinted polymer: a new impedimetric sensor for tributyltin detection.

Alejandro Zamora, Carmen C. Mayorga-Martínez. Electrochemistry Communications, Available online September 2017, doi: 10.1002/adma.201604905
Recently, molecular imprinted polymers (MIPs) were extensively used for separation and identification of specific molecules, replacing expensive and unstable biological receptors. Nonetheless, their application in electrochemical sensors has not been sufficiently explored. Here we report the use of a MIP as a specific receptor in...

Rapid on-chip apoptosis assay on human carcinoma cells based on annexin-V / quantum dot probes

Helena Montón, Mariana Medina-Sánchez, Joan Antoni Soler, Andrzej Chałupniak, Carme Nogués, Arben Merkoçi. Biosensors and Bioelectronics, Available online 18 March 2017, http://dx.doi.org/10.1016/j.bios.2017.03.034
Despite all the efforts made over years to study the cancer expression and the metastasis event, there is not a clear understanding of its origins and effective treatment. Therefore, more specialized and rapid techniques are required for studying cell behaviour under different drug-based treatments. Here we present a quantum dot...

Toward integrated detection and graphene-based removal of contaminants in a lab-on-a-chip platform

Andrzej Chałupniak, Arben Merkoçi. Nano Research (2017), doi:10.1007/s12274-016-1420-3
A novel, miniaturized microfluidic platform was developed for the simultaneous detection and removal of polybrominated diphenyl ethers (PBDEs). The platform consists of a polydimethylsiloxane (PDMS) microfluidic chip for an immunoreaction step, a PDMS chip with an integrated screen-printed electrode (SPCE) for detection, and a PDMS-reduced...

Graphene-Based Biosensors: Going Simple

Eden Morales-Narváez, Luis Baptista-Pires, Alejandro Zamora-Gálvez, and Arben Merkoçi. Advanced Materials, Available online 29 November 2016, doi: 10.1002/adma.201604905
The main properties of graphene derivatives facilitating optical and electrical biosensing platforms are discussed, along with how the integration of graphene derivatives, plastic, and paper can lead to innovative devices in order to simplify biosensing technology and manufacture easy-to-use, yet powerful electrical or optical biosensors....

Mobile phone–based biosensing: an emerging “diagnostic and communication” technology

Daniel Quesada-González, Arben Merkoçi. Biosensors and Bioelectronics, Available online 15 June 2017, https://doi.org/10.1016/j.bios.2016.10.062
In this review we discuss recent developments on the use of mobile phones and similar devices for biosensing applications in which diagnostics and communications are coupled. Owing to the capabilities of mobile phones (their cameras, connectivity, portability, etc.) and to advances in biosensing, the coupling of these two technologies...

Paper-based sensors and assays: a success of the engineering design and the convergence of knowledge areas

Adaris M. López-Marzo and Arben Merkoçi. Lab-on-a-chip, Available online 7 June 2016, doi: 10.1039/C6LC00737F
This review shows the recent advances and state of the art in paper-based analytical devices (PADs) through the analysis of their integration with microfluidics and LOC micro- and nanotechnologies, electrochemical/optical detection and electronic devices as the convergence of various knowledge areas. The important role of the paper...

Nanomaterials-based enzyme electrochemical biosensors operating through inhibition for biosensing applications

Sevinc Kurbanoglu, Sibel A. Ozkan, Arben Merkoçi.. Biosensors and Bioelectronics, Available online 15 March 2017, https://doi.org/10.1016/j.bios.2016.09.102
In recent years great progress has been made in applying nanomaterials to design novel biosensors. Use of nanomaterials offers to biosensing platforms exceptional optical, electronic and magnetic properties. Nanomaterials can increase the surface of the transducing area of the sensors that in turn bring an increase in catalytic behaviors....

Biosensors for plant pathogen detection

Mohga Khater, Alfredo de la Escosura-Muñiz, Arben Merkoçi.. Biosensors and Bioelectronics, Available online 15 July 2017, https://doi.org/10.1016/j.bios.2016.09.091
Infectious plant diseases are caused by pathogenic microorganisms such as fungi, bacteria, viruses, viroids, phytoplasma and nematodes. Worldwide, plant pathogen infections are among main factors limiting crop productivity and increasing economic losses. Plant pathogen detection is important as first step to manage a plant disease...